Drug interactions
Labetalol + Xipamide
Severity: Moderate
Labetalol and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic that lowers blood pressure, and combined with labetalol the effect is additive. This is often intended but can cause excessive hypotension, dizziness or falls, especially in older patients or those volume depleted. Diuretic-induced electrolyte disturbances may also matter.
What this interaction means in plain words
Labetalol and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effects of beta/alpha blockade and diuretic-induced volume and sodium depletion.
What to do
Monitor blood pressure, orthostatic symptoms and electrolytes, and reduce doses if hypotension occurs. Start the combination at low doses in frail patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Xipamide?
MediHelp rates the interaction as moderate. Labetalol and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic that lowers blood pressure, and combined with labetalol the effect is additive. This is often intended but can cause excessive hypotension, dizziness or falls, especially in older patients or those volume depleted. Diuretic-induced electrolyte disturbances may also matter.
How serious is the interaction between Labetalol and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, orthostatic symptoms and electrolytes, and reduce doses if hypotension occurs. Start the combination at low doses in frail patients.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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