Drug interactions
Labetalol + Yohimbe
Severity: Minor
Labetalol and Yohimbe: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe contains yohimbine, an alpha-2 antagonist that raises sympathetic outflow and blood pressure. Labetalol's adrenergic blockade may blunt this effect, while the antihypertensive action of labetalol may be opposed.
What this interaction means in plain words
Labetalol and Yohimbe have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism between alpha-2 adrenergic blockade (yohimbine) and the alpha/beta-blocking effect of labetalol.
What to do
Advise patients to avoid yohimbe supplements and monitor blood pressure if they are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Yohimbe?
MediHelp rates the interaction as minor. Labetalol and Yohimbe have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbe contains yohimbine, an alpha-2 antagonist that raises sympathetic outflow and blood pressure. Labetalol's adrenergic blockade may blunt this effect, while the antihypertensive action of labetalol may be opposed.
How serious is the interaction between Labetalol and Yohimbe?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe supplements and monitor blood pressure if they are used.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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