Drug interactions
Lamotrigine + Lasmiditan
Severity: Moderate
Lamotrigine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and somnolence, and lamotrigine can cause similar effects. Combined use may increase sedation and impair driving or other skilled tasks.
What this interaction means in plain words
Lamotrigine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lamotrigine belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS effects; no pharmacokinetic interaction is established.
What to do
Advise patients not to drive or operate machinery for at least 8 hours after a lasmiditan dose. Monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lamotrigine with Lasmiditan?
MediHelp rates the interaction as moderate. Lamotrigine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and somnolence, and lamotrigine can cause similar effects. Combined use may increase sedation and impair driving or other skilled tasks.
How serious is the interaction between Lamotrigine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients not to drive or operate machinery for at least 8 hours after a lasmiditan dose. Monitor for excessive sedation.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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