Drug interactions
Lamotrigine + Lurasidone
Severity: Minor
Lamotrigine and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and dizziness, so combined use may modestly increase these effects. There is no significant pharmacokinetic interaction, and the combination is commonly used in bipolar depression.
What this interaction means in plain words
Lamotrigine and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lamotrigine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; no meaningful pharmacokinetic interaction.
What to do
No dose change is usually required; counsel patients about drowsiness and review sedation if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Lamotrigine
Frequently asked questions
Can I take Lamotrigine with Lurasidone?
MediHelp rates the interaction as minor. Lamotrigine and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause somnolence and dizziness, so combined use may modestly increase these effects. There is no significant pharmacokinetic interaction, and the combination is commonly used in bipolar depression.
How serious is the interaction between Lamotrigine and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; counsel patients about drowsiness and review sedation if symptoms occur.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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