Drug interactions
Lansoprazole + Letermovir
Severity: Minor
Lansoprazole and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir may change the metabolism of CYP2C19 and CYP2C9 substrates, and the legacy mechanism is not well supported. Any effect on lansoprazole is uncertain and probably small.
What this interaction means in plain words
Lansoprazole and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Letermovir belongs to Anti Virals.
Why it happens
Letermovir induces CYP2C19 and inhibits CYP3A4 modestly; the net effect on lansoprazole is not well established.
What to do
No routine dose change is needed; monitor acid-suppression response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Lansoprazole with Letermovir?
MediHelp rates the interaction as minor. Lansoprazole and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir may change the metabolism of CYP2C19 and CYP2C9 substrates, and the legacy mechanism is not well supported. Any effect on lansoprazole is uncertain and probably small.
How serious is the interaction between Lansoprazole and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor acid-suppression response.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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