Drug interactions
Lansoprazole + Lomitapide
Severity: Moderate
Lansoprazole and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is metabolized by CYP3A4, and weak inhibitors can raise its exposure and increase hepatotoxicity and gastrointestinal effects. Lansoprazole is a weak CYP3A4 inhibitor, so the effect is expected to be limited.
What this interaction means in plain words
Lansoprazole and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lansoprazole belongs to Gastrointestinal Tract; Lomitapide belongs to Cardiovascular.
Why it happens
Lansoprazole weakly inhibits CYP3A4, decreasing lomitapide metabolism.
What to do
Monitor liver enzymes and GI tolerability, and keep the lomitapide dose within the labeled limit for weak CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lansoprazole with Lomitapide?
MediHelp rates the interaction as moderate. Lansoprazole and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is metabolized by CYP3A4, and weak inhibitors can raise its exposure and increase hepatotoxicity and gastrointestinal effects. Lansoprazole is a weak CYP3A4 inhibitor, so the effect is expected to be limited.
How serious is the interaction between Lansoprazole and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and GI tolerability, and keep the lomitapide dose within the labeled limit for weak CYP3A4 inhibitors.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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