Drug interactions
Lansoprazole + Lonafarnib
Severity: Moderate
Lansoprazole and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and lansoprazole may modestly raise its exposure. Lonafarnib also inhibits CYP2C19 and may raise lansoprazole levels, and the cardiac effects of lonafarnib are not fully characterised.
What this interaction means in plain words
Lansoprazole and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lansoprazole belongs to Gastrointestinal Tract; Lonafarnib belongs to Miscellaneous.
Why it happens
Weak CYP3A inhibition by lansoprazole raises lonafarnib levels, and lonafarnib inhibits CYP2C19, reducing lansoprazole clearance.
What to do
If coadministration is needed, keep lonafarnib at its current dose and monitor for palpitations, syncope and gastrointestinal toxicity. Adjust the PPI dose if adverse effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lansoprazole and Lonafarnib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lansoprazole with Lonafarnib?
MediHelp rates the interaction as moderate. Lansoprazole and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate, and lansoprazole may modestly raise its exposure. Lonafarnib also inhibits CYP2C19 and may raise lansoprazole levels, and the cardiac effects of lonafarnib are not fully characterised.
How serious is the interaction between Lansoprazole and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is needed, keep lonafarnib at its current dose and monitor for palpitations, syncope and gastrointestinal toxicity. Adjust the PPI dose if adverse effects arise.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
