Drug interactions
Lansoprazole + Mycophenolate mofetil
Severity: Moderate
Lansoprazole and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Proton pump inhibitors can lower mycophenolic acid exposure after mycophenolate mofetil, because the prodrug depends on acidic conditions for dissolution. The clinical significance is uncertain, and enteric-coated mycophenolate sodium is less affected.
What this interaction means in plain words
Lansoprazole and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lansoprazole belongs to Gastrointestinal Tract; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Elevated gastric pH reduces dissolution and absorption of mycophenolate mofetil.
What to do
Monitor for rejection or loss of efficacy, and consider mycophenolic acid level monitoring. Use the lowest effective PPI dose or consider enteric-coated mycophenolate sodium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Lansoprazole with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Lansoprazole and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Proton pump inhibitors can lower mycophenolic acid exposure after mycophenolate mofetil, because the prodrug depends on acidic conditions for dissolution. The clinical significance is uncertain, and enteric-coated mycophenolate sodium is less affected.
How serious is the interaction between Lansoprazole and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rejection or loss of efficacy, and consider mycophenolic acid level monitoring. Use the lowest effective PPI dose or consider enteric-coated mycophenolate sodium.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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