Drug interactions
Lansoprazole + Nisoldipine
Severity: Minor
Lansoprazole and Nisoldipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy basis for this pair is weak, since nisoldipine is a CYP3A4 substrate and lansoprazole is not a meaningful CYP3A4 inhibitor. Any pH effect on nisoldipine absorption is not well established clinically.
What this interaction means in plain words
Lansoprazole and Nisoldipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Nisoldipine belongs to Cardiovascular.
Why it happens
No well-established mechanism; a minor pH-related effect on absorption is speculative.
What to do
No specific action is required; monitor blood pressure as usual when starting or stopping either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Lansoprazole with Nisoldipine?
MediHelp rates the interaction as minor. Lansoprazole and Nisoldipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The legacy basis for this pair is weak, since nisoldipine is a CYP3A4 substrate and lansoprazole is not a meaningful CYP3A4 inhibitor. Any pH effect on nisoldipine absorption is not well established clinically.
How serious is the interaction between Lansoprazole and Nisoldipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; monitor blood pressure as usual when starting or stopping either drug.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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