Drug interactions
Lansoprazole + Ribociclib
Severity: Minor
Lansoprazole and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and could modestly raise lansoprazole concentrations, since CYP3A4 is a secondary route of lansoprazole metabolism. Clinical significance is expected to be small.
What this interaction means in plain words
Lansoprazole and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, a minor elimination pathway for lansoprazole.
What to do
No dose change is generally required; monitor for PPI adverse effects if long-term high doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Lansoprazole with Ribociclib?
MediHelp rates the interaction as minor. Lansoprazole and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib inhibits CYP3A4 and could modestly raise lansoprazole concentrations, since CYP3A4 is a secondary route of lansoprazole metabolism. Clinical significance is expected to be small.
How serious is the interaction between Lansoprazole and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor for PPI adverse effects if long-term high doses are used.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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