Drug interactions
Lansoprazole + Tazemetostat
Severity: Minor
Lansoprazole and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and a CYP3A4 substrate, and lansoprazole has only minor CYP3A4 involvement. Any change in exposure to either drug is expected to be small.
What this interaction means in plain words
Lansoprazole and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by tazemetostat may slightly lower lansoprazole exposure, while lansoprazole's CYP3A4 inhibition is minimal.
What to do
No dose change is generally required. Monitor for reduced acid suppression if symptoms recur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Lansoprazole with Tazemetostat?
MediHelp rates the interaction as minor. Lansoprazole and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and a CYP3A4 substrate, and lansoprazole has only minor CYP3A4 involvement. Any change in exposure to either drug is expected to be small.
How serious is the interaction between Lansoprazole and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Monitor for reduced acid suppression if symptoms recur.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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