Drug interactions
Lansoprazole + Tecovirimat
Severity: Minor
Lansoprazole and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat weakly inhibits CYP2C19 and weakly induces CYP3A4, both of which contribute to lansoprazole metabolism. The effects are likely to partly offset each other and to be small.
What this interaction means in plain words
Lansoprazole and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Tecovirimat belongs to Miscellaneous.
Why it happens
Tecovirimat weakly inhibits CYP2C19 and weakly induces CYP3A4, which can alter lansoprazole clearance slightly in either direction.
What to do
No empirical dose adjustment is needed. Watch for reduced acid control or increased adverse effects of lansoprazole during a tecovirimat course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Lansoprazole with Tecovirimat?
MediHelp rates the interaction as minor. Lansoprazole and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat weakly inhibits CYP2C19 and weakly induces CYP3A4, both of which contribute to lansoprazole metabolism. The effects are likely to partly offset each other and to be small.
How serious is the interaction between Lansoprazole and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed. Watch for reduced acid control or increased adverse effects of lansoprazole during a tecovirimat course.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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