Drug interactions
Lansoprazole + Voriconazole
Severity: Minor
Lansoprazole and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP2C19 and CYP3A4, the two main enzymes that clear lansoprazole, which can increase lansoprazole exposure. Lansoprazole is generally well tolerated, so the increase is usually of limited consequence, although reciprocal effects on voriconazole may also occur through CYP2C19.
What this interaction means in plain words
Lansoprazole and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C19 and CYP3A4-mediated metabolism of lansoprazole.
What to do
No routine dose adjustment is needed; consider reducing lansoprazole dose if adverse effects emerge, particularly in CYP2C19 poor metabolizers.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Lansoprazole with Voriconazole?
MediHelp rates the interaction as minor. Lansoprazole and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole inhibits CYP2C19 and CYP3A4, the two main enzymes that clear lansoprazole, which can increase lansoprazole exposure. Lansoprazole is generally well tolerated, so the increase is usually of limited consequence, although reciprocal effects on voriconazole may also occur through CYP2C19.
How serious is the interaction between Lansoprazole and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed; consider reducing lansoprazole dose if adverse effects emerge, particularly in CYP2C19 poor metabolizers.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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