Drug interactions
Lapatinib + Lumateperone
Severity: Moderate
Lapatinib and Lumateperone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib may increase lumateperone exposure by inhibiting CYP3A4, which may worsen sedation, orthostatic hypotension and other adverse effects.
What this interaction means in plain words
Lapatinib and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Lumateperone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 metabolism of lumateperone by lapatinib.
What to do
Reduce lumateperone to 21 mg daily as labeled for moderate CYP3A4 inhibitors. Monitor sedation and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Lumateperone
Frequently asked questions
Can I take Lapatinib with Lumateperone?
MediHelp rates the interaction as moderate. Lapatinib and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib may increase lumateperone exposure by inhibiting CYP3A4, which may worsen sedation, orthostatic hypotension and other adverse effects.
How serious is the interaction between Lapatinib and Lumateperone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce lumateperone to 21 mg daily as labeled for moderate CYP3A4 inhibitors. Monitor sedation and blood pressure.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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