Drug interactions
Lapatinib + Metformin-repaglinide
Severity: Moderate
Lapatinib and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and may raise repaglinide concentrations, increasing the risk of hypoglycemia. The effect is likely modest relative to strong inhibitors.
What this interaction means in plain words
Lapatinib and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Metformin-repaglinide belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 (and CYP2C8) by lapatinib reduces repaglinide metabolism.
What to do
Monitor blood glucose and reduce the repaglinide dose if hypoglycemia occurs while on lapatinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Lapatinib and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and may raise repaglinide concentrations, increasing the risk of hypoglycemia. The effect is likely modest relative to strong inhibitors.
How serious is the interaction between Lapatinib and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the repaglinide dose if hypoglycemia occurs while on lapatinib.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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