Drug interactions
Lapatinib + Miconazole
Severity: Moderate
Lapatinib and Miconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is a CYP3A4 substrate, and strong inhibitors substantially raise its exposure. Miconazole may increase lapatinib levels, with vaginal use giving a smaller effect. Higher levels increase the risk of diarrhea, hepatotoxicity and QT prolongation.
What this interaction means in plain words
Lapatinib and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4, reducing lapatinib clearance.
What to do
Monitor for diarrhea, liver enzymes and QT interval during miconazole use. Prefer a non-azole alternative or a topical agent with minimal absorption when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miconazole
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Miconazole?
MediHelp rates the interaction as moderate. Lapatinib and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib is a CYP3A4 substrate, and strong inhibitors substantially raise its exposure. Miconazole may increase lapatinib levels, with vaginal use giving a smaller effect. Higher levels increase the risk of diarrhea, hepatotoxicity and QT prolongation.
How serious is the interaction between Lapatinib and Miconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, liver enzymes and QT interval during miconazole use. Prefer a non-azole alternative or a topical agent with minimal absorption when possible.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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