Drug interactions
Lapatinib + Nifedipine
Severity: Minor
Lapatinib and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and P-glycoprotein and may raise nifedipine exposure, leading to hypotension and edema. Nifedipine is a weak inhibitor and is unlikely to change lapatinib exposure substantially.
What this interaction means in plain words
Lapatinib and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lapatinib belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Lapatinib inhibits CYP3A4 and P-glycoprotein, which may modestly increase nifedipine exposure.
What to do
Monitor blood pressure and consider lowering the nifedipine dose if hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Nifedipine?
MediHelp rates the interaction as minor. Lapatinib and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib inhibits CYP3A4 and P-glycoprotein and may raise nifedipine exposure, leading to hypotension and edema. Nifedipine is a weak inhibitor and is unlikely to change lapatinib exposure substantially.
How serious is the interaction between Lapatinib and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and consider lowering the nifedipine dose if hypotension develops.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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