Drug interactions
Lapatinib + Ofloxacin
Severity: Moderate
Lapatinib and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib and ofloxacin can each prolong the QT interval. Using them together may increase the likelihood of torsades de pointes, especially with electrolyte disturbance or other QT-prolonging drugs.
What this interaction means in plain words
Lapatinib and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive delayed cardiac repolarization through potassium channel effects.
What to do
Check baseline ECG and correct potassium and magnesium before combining. Repeat the ECG if symptoms or other risk factors appear, or choose a non-QT-prolonging antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Ofloxacin?
MediHelp rates the interaction as moderate. Lapatinib and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib and ofloxacin can each prolong the QT interval. Using them together may increase the likelihood of torsades de pointes, especially with electrolyte disturbance or other QT-prolonging drugs.
How serious is the interaction between Lapatinib and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before combining. Repeat the ECG if symptoms or other risk factors appear, or choose a non-QT-prolonging antibiotic.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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