Drug interactions
Lapatinib + Palifermin
Severity: Moderate
Lapatinib and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth and may worsen mucositis if given close to cytotoxic therapy. Its use around lapatinib is not established, and the concern is extrapolated from chemotherapy experience.
What this interaction means in plain words
Lapatinib and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-induced epithelial proliferation may sensitize mucosal cells to antineoplastic injury.
What to do
Avoid giving palifermin within 24 hours of cytotoxic therapy, and monitor oral mucositis if the combination is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Palifermin
Frequently asked questions
Can I take Lapatinib with Palifermin?
MediHelp rates the interaction as moderate. Lapatinib and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin stimulates epithelial cell growth and may worsen mucositis if given close to cytotoxic therapy. Its use around lapatinib is not established, and the concern is extrapolated from chemotherapy experience.
How serious is the interaction between Lapatinib and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving palifermin within 24 hours of cytotoxic therapy, and monitor oral mucositis if the combination is used.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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