Drug interactions
Lapatinib + Safinamide
Severity: Moderate
Lapatinib and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is an orally administered BCRP substrate, so intestinal BCRP inhibition by safinamide may raise its exposure. This could increase diarrhea, rash, hepatotoxicity and QT effects.
What this interaction means in plain words
Lapatinib and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Safinamide belongs to Central Nervous System.
Why it happens
Safinamide inhibits intestinal BCRP, increasing the oral absorption of lapatinib.
What to do
Monitor for lapatinib adverse effects and liver function. Reduce the lapatinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Safinamide?
MediHelp rates the interaction as moderate. Lapatinib and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib is an orally administered BCRP substrate, so intestinal BCRP inhibition by safinamide may raise its exposure. This could increase diarrhea, rash, hepatotoxicity and QT effects.
How serious is the interaction between Lapatinib and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lapatinib adverse effects and liver function. Reduce the lapatinib dose if toxicity occurs.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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