Drug interactions
Lapatinib + Sorafenib
Severity: Moderate
Lapatinib and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combination may add to arrhythmia risk. Electrolyte disturbances or cardiac disease increase the concern.
What this interaction means in plain words
Lapatinib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG and monitor QTc periodically. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Lapatinib with Sorafenib?
MediHelp rates the interaction as moderate. Lapatinib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combination may add to arrhythmia risk. Electrolyte disturbances or cardiac disease increase the concern.
How serious is the interaction between Lapatinib and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc periodically. Correct potassium and magnesium abnormalities.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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