Drug interactions
Lapatinib + Telavancin
Severity: Moderate
Lapatinib and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib carries a labeled warning for QT prolongation and telavancin may also lengthen the QTc. Together they may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Lapatinib and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Telavancin belongs to Anti Bacterial.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Perform a baseline and periodic ECG and correct electrolyte abnormalities before and during therapy. Consider an alternative antibacterial if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Telavancin?
MediHelp rates the interaction as moderate. Lapatinib and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib carries a labeled warning for QT prolongation and telavancin may also lengthen the QTc. Together they may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Lapatinib and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline and periodic ECG and correct electrolyte abnormalities before and during therapy. Consider an alternative antibacterial if the QTc becomes markedly prolonged.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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