Drug interactions
Lapatinib + Triamcinolone
Severity: Moderate
Lapatinib and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and may raise triamcinolone exposure, increasing the risk of corticosteroid adverse effects such as adrenal suppression and Cushingoid features. The effect is more relevant with repeated or high-dose triamcinolone.
What this interaction means in plain words
Lapatinib and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Triamcinolone belongs to Endocrine.
Why it happens
Lapatinib inhibits CYP3A4, reducing triamcinolone metabolic clearance.
What to do
Monitor for signs of corticosteroid excess and adrenal suppression, and consider limiting the triamcinolone dose or injection frequency during lapatinib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Triamcinolone?
MediHelp rates the interaction as moderate. Lapatinib and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and may raise triamcinolone exposure, increasing the risk of corticosteroid adverse effects such as adrenal suppression and Cushingoid features. The effect is more relevant with repeated or high-dose triamcinolone.
How serious is the interaction between Lapatinib and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess and adrenal suppression, and consider limiting the triamcinolone dose or injection frequency during lapatinib therapy.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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