Drug interactions
Lapatinib + Triptorelin
Severity: Moderate
Lapatinib and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both triptorelin and lapatinib can prolong the QT interval. Combined use may increase the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Lapatinib and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Triptorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check baseline and periodic ECGs and keep potassium and magnesium within normal range. Avoid other QT-prolonging drugs where possible and reduce or stop lapatinib if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triptorelin
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Triptorelin?
MediHelp rates the interaction as moderate. Lapatinib and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both triptorelin and lapatinib can prolong the QT interval. Combined use may increase the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Lapatinib and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and periodic ECGs and keep potassium and magnesium within normal range. Avoid other QT-prolonging drugs where possible and reduce or stop lapatinib if the QTc becomes markedly prolonged.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
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