Drug interactions
Lapatinib + Vinorelbine
Severity: Moderate
Lapatinib and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and P-glycoprotein, and vinorelbine is a CYP3A4 and P-gp substrate, so vinorelbine exposure may increase. Greater neutropenia and neuropathy are possible, and both drugs can cause myelosuppression or other toxicity.
What this interaction means in plain words
Lapatinib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Lapatinib inhibition of CYP3A4 and P-glycoprotein may reduce vinorelbine clearance.
What to do
Monitor neutrophil counts and neuropathy, and reduce the vinorelbine dose if significant toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Vinorelbine?
MediHelp rates the interaction as moderate. Lapatinib and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and P-glycoprotein, and vinorelbine is a CYP3A4 and P-gp substrate, so vinorelbine exposure may increase. Greater neutropenia and neuropathy are possible, and both drugs can cause myelosuppression or other toxicity.
How serious is the interaction between Lapatinib and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and neuropathy, and reduce the vinorelbine dose if significant toxicity occurs.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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