Drug interactions
Larotrectinib + Metaxalone
Severity: Minor
Larotrectinib and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor, so it may modestly raise metaxalone levels. The clinical effect is likely small, with a possible increase in sedation.
What this interaction means in plain words
Larotrectinib and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Metaxalone belongs to Musculoskeletal.
Why it happens
Larotrectinib inhibits CYP3A4, slightly reducing metaxalone clearance.
What to do
Monitor for increased drowsiness or dizziness and reduce the metaxalone dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Metaxalone?
MediHelp rates the interaction as minor. Larotrectinib and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor, so it may modestly raise metaxalone levels. The clinical effect is likely small, with a possible increase in sedation.
How serious is the interaction between Larotrectinib and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness or dizziness and reduce the metaxalone dose if needed.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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