Drug interactions
Larotrectinib + Nicardipine
Severity: Minor
Larotrectinib and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and weak inhibitor of CYP3A4 in vitro, so nicardipine levels could rise slightly. Clinical relevance is likely small.
What this interaction means in plain words
Larotrectinib and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reduces nicardipine metabolism.
What to do
Monitor blood pressure and for edema or flushing; adjust nicardipine if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Nicardipine?
MediHelp rates the interaction as minor. Larotrectinib and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and weak inhibitor of CYP3A4 in vitro, so nicardipine levels could rise slightly. Clinical relevance is likely small.
How serious is the interaction between Larotrectinib and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema or flushing; adjust nicardipine if needed.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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