Drug interactions
Larotrectinib + Nimodipine
Severity: Minor
Larotrectinib and Nimodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib may modestly inhibit CYP3A4 and raise nimodipine exposure. This could lead to hypotension and flushing, though the effect is probably small.
What this interaction means in plain words
Larotrectinib and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Nimodipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by larotrectinib decreases nimodipine clearance.
What to do
Monitor blood pressure after larotrectinib is started and adjust the nimodipine dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Nimodipine?
MediHelp rates the interaction as minor. Larotrectinib and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib may modestly inhibit CYP3A4 and raise nimodipine exposure. This could lead to hypotension and flushing, though the effect is probably small.
How serious is the interaction between Larotrectinib and Nimodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after larotrectinib is started and adjust the nimodipine dose if hypotension occurs.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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