Drug interactions
Larotrectinib + Paclitaxel
Severity: Minor
Larotrectinib and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory activity in vitro, and a meaningful effect on paclitaxel exposure has not been established. Any increase in paclitaxel levels is likely small.
What this interaction means in plain words
Larotrectinib and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib; the clinical mechanism is not established.
What to do
No dose adjustment is needed; monitor for paclitaxel toxicity such as neutropenia and neuropathy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Paclitaxel?
MediHelp rates the interaction as minor. Larotrectinib and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory activity in vitro, and a meaningful effect on paclitaxel exposure has not been established. Any increase in paclitaxel levels is likely small.
How serious is the interaction between Larotrectinib and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for paclitaxel toxicity such as neutropenia and neuropathy.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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