Drug interactions
Larotrectinib + Quinidine
Severity: Minor
Larotrectinib and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory potential in vitro, and a clinically meaningful effect on quinidine is not established. The effect is theoretical.
What this interaction means in plain words
Larotrectinib and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib; not clinically established.
What to do
Monitor ECG if quinidine is used with larotrectinib and adjust quinidine only if signs of increased exposure occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Quinidine?
MediHelp rates the interaction as minor. Larotrectinib and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory potential in vitro, and a clinically meaningful effect on quinidine is not established. The effect is theoretical.
How serious is the interaction between Larotrectinib and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG if quinidine is used with larotrectinib and adjust quinidine only if signs of increased exposure occur.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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