Drug interactions
Larotrectinib + Regorafenib
Severity: Minor
Larotrectinib and Regorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a weak CYP3A4 inhibitor in vitro and may slightly increase regorafenib levels. Clinical impact is probably small but could add to regorafenib toxicity.
What this interaction means in plain words
Larotrectinib and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Regorafenib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by larotrectinib reducing regorafenib metabolism.
What to do
No dose change is usually required; monitor liver tests and for regorafenib adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Regorafenib
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Regorafenib?
MediHelp rates the interaction as minor. Larotrectinib and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a weak CYP3A4 inhibitor in vitro and may slightly increase regorafenib levels. Clinical impact is probably small but could add to regorafenib toxicity.
How serious is the interaction between Larotrectinib and Regorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor liver tests and for regorafenib adverse effects.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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