Drug interactions
Larotrectinib + Tamsulosin
Severity: Minor
Larotrectinib and Tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a weak CYP3A4 inhibitor and may modestly increase tamsulosin exposure. Clinically significant effects are unlikely but dizziness or hypotension could occur.
What this interaction means in plain words
Larotrectinib and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Tamsulosin belongs to Genitourinary.
Why it happens
Larotrectinib weakly inhibits CYP3A4, reducing tamsulosin metabolism.
What to do
Ask about dizziness on standing after larotrectinib is started. Adjust the tamsulosin dose only if symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Tamsulosin?
MediHelp rates the interaction as minor. Larotrectinib and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a weak CYP3A4 inhibitor and may modestly increase tamsulosin exposure. Clinically significant effects are unlikely but dizziness or hypotension could occur.
How serious is the interaction between Larotrectinib and Tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about dizziness on standing after larotrectinib is started. Adjust the tamsulosin dose only if symptoms develop.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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