Drug interactions
Larotrectinib + Ticagrelor
Severity: Minor
Larotrectinib and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib may weakly inhibit CYP3A4 and could slightly raise ticagrelor levels. Clinical significance is probably small.
What this interaction means in plain words
Larotrectinib and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib.
What to do
Monitor for bleeding; no dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Ticagrelor?
MediHelp rates the interaction as minor. Larotrectinib and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib may weakly inhibit CYP3A4 and could slightly raise ticagrelor levels. Clinical significance is probably small.
How serious is the interaction between Larotrectinib and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding; no dose change is usually needed.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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