Drug interactions
Larotrectinib + Vardenafil
Severity: Minor
Larotrectinib and Vardenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is mainly a CYP3A4 substrate and has only weak inhibitory potential on CYP3A4, so any rise in vardenafil exposure is likely small. Effects would be mainly increased vasodilatory adverse effects.
What this interaction means in plain words
Larotrectinib and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Vardenafil belongs to Genitourinary.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib; the interaction is not well established.
What to do
Monitor blood pressure and tolerability; reduce the vardenafil dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Vardenafil?
MediHelp rates the interaction as minor. Larotrectinib and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is mainly a CYP3A4 substrate and has only weak inhibitory potential on CYP3A4, so any rise in vardenafil exposure is likely small. Effects would be mainly increased vasodilatory adverse effects.
How serious is the interaction between Larotrectinib and Vardenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability; reduce the vardenafil dose if adverse effects appear.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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