Drug interactions
Larotrectinib + Verapamil
Severity: Moderate
Larotrectinib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may raise larotrectinib exposure through CYP3A4 inhibition. Increased levels could worsen neurologic effects, hepatotoxicity and other adverse reactions.
What this interaction means in plain words
Larotrectinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Larotrectinib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4-mediated metabolism of larotrectinib.
What to do
Where possible avoid the combination; otherwise monitor for larotrectinib toxicity and liver enzymes, and reduce its dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Verapamil?
MediHelp rates the interaction as moderate. Larotrectinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may raise larotrectinib exposure through CYP3A4 inhibition. Increased levels could worsen neurologic effects, hepatotoxicity and other adverse reactions.
How serious is the interaction between Larotrectinib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible avoid the combination; otherwise monitor for larotrectinib toxicity and liver enzymes, and reduce its dose if adverse effects occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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