Drug interactions
Larotrectinib + Vinblastine
Severity: Minor
Larotrectinib and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak inhibitor of the enzyme, so it could slightly raise vinblastine exposure. The clinical importance is probably limited.
What this interaction means in plain words
Larotrectinib and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by larotrectinib may modestly reduce vinblastine clearance.
What to do
Monitor for vinblastine toxicity such as neutropenia and neuropathy. No empirical dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinblastine
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Vinblastine?
MediHelp rates the interaction as minor. Larotrectinib and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak inhibitor of the enzyme, so it could slightly raise vinblastine exposure. The clinical importance is probably limited.
How serious is the interaction between Larotrectinib and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vinblastine toxicity such as neutropenia and neuropathy. No empirical dose change is needed.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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