Drug interactions
Lasmiditan + Meclizine
Severity: Moderate
Lasmiditan and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan can cause sedation, dizziness and cognitive effects, and meclizine can add to these. Combined use may increase impairment.
What this interaction means in plain words
Lasmiditan and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Meclizine belongs to Respiratory.
Why it happens
Additive CNS depression from 5-HT1F agonist effects and H1-antihistamine sedation.
What to do
Counsel patients not to drive for at least 8 hours after lasmiditan and to avoid other sedatives around dosing. Monitor for excessive drowsiness and dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclizine
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Meclizine?
MediHelp rates the interaction as moderate. Lasmiditan and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan can cause sedation, dizziness and cognitive effects, and meclizine can add to these. Combined use may increase impairment.
How serious is the interaction between Lasmiditan and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to drive for at least 8 hours after lasmiditan and to avoid other sedatives around dosing. Monitor for excessive drowsiness and dizziness.
What other medicines interact with Meclizine?
MediHelp also lists interactions of Meclizine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Meclizine page.
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