Drug interactions
Lasmiditan + Methotrexate
Severity: Moderate
Lasmiditan and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits BCRP in vitro, so it may raise exposure to methotrexate, which is a BCRP substrate. The clinical relevance is unconfirmed, but higher methotrexate levels could increase toxicity.
What this interaction means in plain words
Lasmiditan and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Methotrexate belongs to Oncology.
Why it happens
Inhibition of BCRP efflux transport by lasmiditan may reduce methotrexate elimination.
What to do
Lasmiditan is used intermittently, so monitor for methotrexate toxicity with frequent use. Check blood counts and liver and renal function if the patient takes it regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Methotrexate?
MediHelp rates the interaction as moderate. Lasmiditan and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits BCRP in vitro, so it may raise exposure to methotrexate, which is a BCRP substrate. The clinical relevance is unconfirmed, but higher methotrexate levels could increase toxicity.
How serious is the interaction between Lasmiditan and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lasmiditan is used intermittently, so monitor for methotrexate toxicity with frequent use. Check blood counts and liver and renal function if the patient takes it regularly.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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