Drug interactions
Lasmiditan + Olanzapine
Severity: Moderate
Lasmiditan and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan causes dizziness and sedation, and olanzapine is also sedating. Together they may increase drowsiness and impair alertness and psychomotor performance.
What this interaction means in plain words
Lasmiditan and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Advise patients not to drive or operate machinery for at least 8 hours after lasmiditan. Monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Olanzapine?
MediHelp rates the interaction as moderate. Lasmiditan and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan causes dizziness and sedation, and olanzapine is also sedating. Together they may increase drowsiness and impair alertness and psychomotor performance.
How serious is the interaction between Lasmiditan and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients not to drive or operate machinery for at least 8 hours after lasmiditan. Monitor for excessive sedation.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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