Drug interactions
Lasmiditan + Pitavastatin
Severity: Moderate
Lasmiditan and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits BCRP in vitro and may increase exposure to BCRP substrates such as pitavastatin. The clinical effect is not well characterized but could raise the risk of statin-related muscle adverse effects.
What this interaction means in plain words
Lasmiditan and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Pitavastatin belongs to Cardiovascular.
Why it happens
Lasmiditan inhibits BCRP, potentially reducing efflux of pitavastatin.
What to do
Monitor for muscle pain or weakness when lasmiditan is used with pitavastatin. Consider a lower pitavastatin dose if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Pitavastatin?
MediHelp rates the interaction as moderate. Lasmiditan and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits BCRP in vitro and may increase exposure to BCRP substrates such as pitavastatin. The clinical effect is not well characterized but could raise the risk of statin-related muscle adverse effects.
How serious is the interaction between Lasmiditan and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain or weakness when lasmiditan is used with pitavastatin. Consider a lower pitavastatin dose if symptoms appear.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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