Drug interactions
Lasmiditan + Propranolol
Severity: Moderate
Lasmiditan and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan can lower heart rate, and with propranolol the reduction was greater than with propranolol alone. This may cause symptomatic bradycardia in some patients.
What this interaction means in plain words
Lasmiditan and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Propranolol belongs to Cardiovascular.
Why it happens
Additive heart rate lowering by lasmiditan and beta blockade.
What to do
Monitor heart rate and watch for dizziness or syncope when lasmiditan is used with propranolol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Propranolol?
MediHelp rates the interaction as moderate. Lasmiditan and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan can lower heart rate, and with propranolol the reduction was greater than with propranolol alone. This may cause symptomatic bradycardia in some patients.
How serious is the interaction between Lasmiditan and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and watch for dizziness or syncope when lasmiditan is used with propranolol.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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