Drug interactions
Lasmiditan + Remifentanil
Severity: Moderate
Lasmiditan and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and somnolence, and remifentanil is a potent opioid sedative. Combined use may intensify drowsiness and cognitive or psychomotor impairment, although formal studies of this pairing are lacking.
What this interaction means in plain words
Lasmiditan and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; lasmiditan acts as a 5-HT1F agonist with sedative adverse effects, while remifentanil acts on mu-opioid receptors.
What to do
Monitor sedation and respiratory status when both are given. Advise patients not to drive or operate machinery for at least 8 hours after lasmiditan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Remifentanil?
MediHelp rates the interaction as moderate. Lasmiditan and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and somnolence, and remifentanil is a potent opioid sedative. Combined use may intensify drowsiness and cognitive or psychomotor impairment, although formal studies of this pairing are lacking.
How serious is the interaction between Lasmiditan and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status when both are given. Advise patients not to drive or operate machinery for at least 8 hours after lasmiditan.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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