Drug interactions
Lasmiditan + Tenofovir disoproxil
Severity: Minor
Lasmiditan and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-gp and BCRP in vitro and may increase exposure to substrates of these transporters. Tenofovir is a P-gp substrate, so tenofovir concentrations could rise modestly, though clinical significance is uncertain.
What this interaction means in plain words
Lasmiditan and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal P-gp and BCRP efflux transporters increases tenofovir absorption.
What to do
Lasmiditan is used intermittently, so no routine adjustment is needed. Monitor renal function in patients with existing kidney impairment who use it frequently.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Lasmiditan and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-gp and BCRP in vitro and may increase exposure to substrates of these transporters. Tenofovir is a P-gp substrate, so tenofovir concentrations could rise modestly, though clinical significance is uncertain.
How serious is the interaction between Lasmiditan and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lasmiditan is used intermittently, so no routine adjustment is needed. Monitor renal function in patients with existing kidney impairment who use it frequently.
What other medicines interact with Lasmiditan?
MediHelp also lists interactions of Lasmiditan with, for example, Alprazolam, Amiodarone, Amisulpride. The full list is on the Lasmiditan page.
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