Drug interactions
Lasmiditan + Triprolidine
Severity: Moderate
Lasmiditan and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes somnolence, dizziness and cognitive effects, and triprolidine is a sedating antihistamine. Together they may increase drowsiness and impair psychomotor performance.
What this interaction means in plain words
Lasmiditan and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depressant and sedative effects.
What to do
Warn patients about additive sedation and advise no driving for at least 8 hours after lasmiditan. Prefer a non-sedating antihistamine when one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Triprolidine?
MediHelp rates the interaction as moderate. Lasmiditan and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes somnolence, dizziness and cognitive effects, and triprolidine is a sedating antihistamine. Together they may increase drowsiness and impair psychomotor performance.
How serious is the interaction between Lasmiditan and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about additive sedation and advise no driving for at least 8 hours after lasmiditan. Prefer a non-sedating antihistamine when one is needed.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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