Drug interactions
Lasmiditan + Venlafaxine
Severity: Moderate
Lasmiditan and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and sedation, which venlafaxine may worsen. Both act on the serotonergic system, so serotonin syndrome is a theoretical concern, although lasmiditan is a 5-HT1F agonist with little 5-HT1B/1D activity.
What this interaction means in plain words
Lasmiditan and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive CNS depression and possible additive serotonergic effects.
What to do
Advise patients not to drive for at least 8 hours after lasmiditan. Monitor for signs of serotonin syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lasmiditan and Venlafaxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Venlafaxine?
MediHelp rates the interaction as moderate. Lasmiditan and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and sedation, which venlafaxine may worsen. Both act on the serotonergic system, so serotonin syndrome is a theoretical concern, although lasmiditan is a 5-HT1F agonist with little 5-HT1B/1D activity.
How serious is the interaction between Lasmiditan and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients not to drive for at least 8 hours after lasmiditan. Monitor for signs of serotonin syndrome.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
