Drug interactions
Lasmiditan + Zaleplon
Severity: Moderate
Lasmiditan and Zaleplon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and somnolence and can impair driving, and zaleplon adds sedation. The combination may increase drowsiness and psychomotor impairment.
What this interaction means in plain words
Lasmiditan and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Zaleplon belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; the combination has not been formally studied.
What to do
Counsel the patient to avoid driving or hazardous activities for at least 8 hours after lasmiditan. Monitor for excess sedation and avoid taking zaleplon at times that overlap with peak lasmiditan effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Zaleplon?
MediHelp rates the interaction as moderate. Lasmiditan and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and somnolence and can impair driving, and zaleplon adds sedation. The combination may increase drowsiness and psychomotor impairment.
How serious is the interaction between Lasmiditan and Zaleplon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid driving or hazardous activities for at least 8 hours after lasmiditan. Monitor for excess sedation and avoid taking zaleplon at times that overlap with peak lasmiditan effects.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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