Drug interactions
Lasmiditan + Zolpidem
Severity: Moderate
Lasmiditan and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause central nervous system depression, and lasmiditan commonly causes dizziness and somnolence. Taken together they may increase sedation, impaired coordination and reduced alertness. The combination has not been formally studied.
What this interaction means in plain words
Lasmiditan and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS depressant pharmacodynamic effects.
What to do
Advise patients not to drive or operate machinery for at least 8 hours after lasmiditan. Avoid taking zolpidem close to a lasmiditan dose when possible and monitor for excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Zolpidem?
MediHelp rates the interaction as moderate. Lasmiditan and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause central nervous system depression, and lasmiditan commonly causes dizziness and somnolence. Taken together they may increase sedation, impaired coordination and reduced alertness. The combination has not been formally studied.
How serious is the interaction between Lasmiditan and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients not to drive or operate machinery for at least 8 hours after lasmiditan. Avoid taking zolpidem close to a lasmiditan dose when possible and monitor for excess sedation.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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