Drug interactions
Ledipasvir-sofosbuvir + Leniolisib
Severity: Moderate
Ledipasvir-sofosbuvir and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP and may raise exposure to BCRP substrates such as ledipasvir and sofosbuvir. The antivirals have a wide therapeutic margin, so the clinical effect is expected to be small.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ledipasvir-sofosbuvir belongs to Anti Virals; Leniolisib belongs to Miscellaneous.
Why it happens
Leniolisib inhibits BCRP, reducing efflux of ledipasvir/sofosbuvir and increasing exposure.
What to do
Coadministration is possible with monitoring for antiviral adverse effects such as fatigue, headache and nausea. Avoid it if a suitable alternative exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Leniolisib?
MediHelp rates the interaction as moderate. Ledipasvir-sofosbuvir and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP and may raise exposure to BCRP substrates such as ledipasvir and sofosbuvir. The antivirals have a wide therapeutic margin, so the clinical effect is expected to be small.
How serious is the interaction between Ledipasvir-sofosbuvir and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Coadministration is possible with monitoring for antiviral adverse effects such as fatigue, headache and nausea. Avoid it if a suitable alternative exists.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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