Drug interactions
Ledipasvir-sofosbuvir + Naldemedine
Severity: Moderate
Ledipasvir-sofosbuvir and Naldemedine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir inhibits P-gp and may increase naldemedine exposure. This can increase gastrointestinal effects such as abdominal pain and diarrhea, or opioid withdrawal symptoms.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ledipasvir-sofosbuvir belongs to Anti Virals; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
P-gp inhibition by ledipasvir increases naldemedine absorption and reduces its efflux.
What to do
Monitor for abdominal pain, diarrhea and opioid withdrawal symptoms; no routine dose change is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Naldemedine?
MediHelp rates the interaction as moderate. Ledipasvir-sofosbuvir and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir inhibits P-gp and may increase naldemedine exposure. This can increase gastrointestinal effects such as abdominal pain and diarrhea, or opioid withdrawal symptoms.
How serious is the interaction between Ledipasvir-sofosbuvir and Naldemedine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal pain, diarrhea and opioid withdrawal symptoms; no routine dose change is needed.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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