Drug interactions
Ledipasvir-sofosbuvir + Nizatidine
Severity: Moderate
Ledipasvir-sofosbuvir and Nizatidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nizatidine raises gastric pH, which can modestly lower ledipasvir absorption. At modest doses the effect is limited and manageable with timing.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ledipasvir-sofosbuvir belongs to Anti Virals; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Reduced gastric acidity decreases ledipasvir solubility and absorption.
What to do
Give nizatidine simultaneously with or 12 hours apart from ledipasvir/sofosbuvir, keeping the dose at or below famotidine 40 mg twice-daily equivalence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Nizatidine?
MediHelp rates the interaction as moderate. Ledipasvir-sofosbuvir and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nizatidine raises gastric pH, which can modestly lower ledipasvir absorption. At modest doses the effect is limited and manageable with timing.
How serious is the interaction between Ledipasvir-sofosbuvir and Nizatidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give nizatidine simultaneously with or 12 hours apart from ledipasvir/sofosbuvir, keeping the dose at or below famotidine 40 mg twice-daily equivalence.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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